Dra. Liliana M. Cancela



Cargo
Investigadora Principal CONICET - Profesora Emérita UNC

Contact
lcancela@unc.edu.ar

Líneas de investigación
Estrés y Vulnerabilidad a la Adicción a Cocaína: Mecanismos Neurobiológicos Implicados

Publicaciones de los últimos 5 años

Avalos MP, Guzman AS, Rigoni D, Gorostiza EA, Sanchez MA, Mongi-Bragato B, García-Keller C, Perassi EM, Virgolini MB, Peralta-Ramos JM, Iribarren P, Calfa GD, Bollati FA, Cancela LM. Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia.  Brain Behav Immun 101, 359-376 (2022). https://doi.org/10.1016/j.bbi.2022.01.014

Guzman AS, Avalos MP, De Giovanni LN, Euliarte PV, Sanchez, M, Rigoni D, Mongi Bragato B, Virgolini MB, Bollati FA, Cancela LM (2021). CB1R activation in nucleus accumbens core promotes stress-induced reinstatement of cocaine seeking by elevating extracellular glutamate in a drug-paired context.  Sci Rep 11, 12964. https://doi.org/10.1038/s41598-021-92389-4

Rigoni D, Avalos MP, Boezio MJ, Guzman AS, Calfa GD, Perassi EM, Pierotti SM, Bisbal M, García-Keller C, Cancela LM*, Bollati F* (2021). Stress-induced vulnerability to develop cocaine addiction depends on cofilin modulation. Neurobiol Stress 15, 100349. *corresponding author. https://doi.org/10.1016/j.ynstr.2021.100349

Mongi-Bragato B, Ávalos MP, Guzman AS, García-Keller C, Bollati F, Cancela LM (2020). Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus Accumbens. Eur J Neurosci 53,1441. https://doi.org/10.1111/ejn.15035

Mattalloni MS, Deza-Ponzio R, Albrecht PA, Fernandez-Hubeid LE, Cancela LM, Virgolini MB (2019). Brain ethanol-metabolizing enzymes are differentially expressed in lead-exposed animals after voluntary ethanol consumption: Pharmacological approaches. Neurotoxicology. 2019 Dec; 75:174-185. https://doi.org/10.1016/j.neuro.2019.09.011 

Bartos M, Gumilar F, Gallegos CE, Bras C, Dominguez S, Cancela LM, Minetti A (2019). Effects of Perinatal Fluoride Exposure on Short- and Long-Term Memory, Brain Antioxidant Status, and Glutamate Metabolism of Young Rat Pups. Int J Toxicol. Sep/Oct;38(5):405-414. https://doi.org/10.1177/1091581819857558

Mattalloni MS, Albrecht PA, Salinas-Luypaert C, Deza-Ponzio R, Quintanilla ME, Herrera-Marschitz M, Cancela LM, Rivera-Meza M, Virgolini MB (2019). Silencing brain catalase expression reduces ethanol intake in developmentally-lead-exposed rats. Neurotoxicology. Jan; 70:180-186. https://doi.org/10.1016/j.neuro.2018.10.010

Mongi-Bragato B, Ávalos MP, Guzman AS, Bollati F, Cancela LM (2018). Enkephalin as a Pivotal Player in Neuroadaptations Related to Psychostimulant Addiction. Frontiers in Psychiatry 9,222. https://doi.org/10.3389/fpsyt.2018.00222

Bartos M, Gumilar F, Gallegos CE, Bras C, Dominguez S, Mónaco N, Esandi MDC, Bouzat C, Cancela LM, Minetti A (2018). Alterations in the memory of rat offspring exposed to low levels of fluoride during gestation and lactation: Involvement of the α7 nicotinic receptor and oxidative stress. Reprod Toxicol. 2018 Oct; 81:108-114. https://doi.org/10.1016/j.reprotox.2018.07.078

Arroyo DS, Gaviglio EA, Peralta Ramos JM, Bussi C, Avalos MP, Cancela LM, Iribarren P (2018). PI3K inhibitors regulate peptidoglycan-induced myeloid leukocyte recruitment, inflammation and neurotoxicity in mouse brain. Frontiers in Immunology, section Inflammation. Apr 17; 9:770. https://doi.org/10.3389/fimmu.2018.00770

Virgolini MB, Mattalloni MS, Albrecht PA, Deza-Ponzio R, Cancela LM (2017). Modulation of Ethanol-Metabolizing Enzymes by Developmental Lead Exposure: Effects in Voluntary Ethanol Consumption. Front. Behav. Neurosci, 11-95. https://doi.org/10.3389/fnbeh.2017.00095

Mattalloni MS; Deza-Ponzio R; Albrecht PA; Cancela LM, Virgolini MB (2017). Developmental lead exposure induces opposite effects on ethanol intake and locomotion in response to central vs. Systemic cyanamide administration. Alcohol, 58:1-11.

De Giovanni LN, Guzman AS, Virgolini MB, Cancela LM (2016). NMDA antagonist MK 801 in nucleus accumbens core but not shell disrupts the restraint stress-induced reinstatement of extinguished cocaine-conditioned place preference in rats. Behav Brain Res 315, 150-9. https://doi.org/10.1016/j.bbr.2016.08.011

Garcia-Keller C, Kupchik Y, Bollati F, Esparza MA, Roberts-Wolfe D, Gipson C, Cancela LM. Kalivas PW (2016). Glutamatergic Mechanisms of Comorbidity Between Stress Disorders and Cocaine Molecular Psychiatry.  21(8):1063-9. https://doi.org/10.1038/mp.2015.151. 

Bartos M, Gumilar F, Bras C, Gallegos CE, Giannuzzi L, Cancela LM, Minetti A (2015). Neurobehavioural effects of exposure to fluoride in the earliest stages of rat development. Physiology and Behavior, 147:205–212. https://doi.org/10.1016/j.alcohol.2016.11.002 

Mongi-Bragato B, Zamponi E, García-Keller C, Assis MA, Virgolini M, Mascó D, Zimmer A, Cancela LM (2016). Enkephalin is essential for the molecular and behavioral expression of cocaine sensitization. Addict Biol, 21(2):326-38. https://doi.org/10.1111/adb.12200

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