Cargo
Investigadora Independiente CONICET - Profesora Asociada UNC
Contact
claudia.herenu@unc.edu.ar
Líneas de investigación
Publicaciones de los últimos 5 años
Macarena Lorena Herrera, Leandro Gabriel Champarini, Alberto Leandro Oliveros, Maria José Bellini* and Claudia Beatriz Hereñú*. Potentialities of IGF-1 for regulating oxidative stress in neuroinflammation and neurodegeneration: theoretical review. Exploration of Neuroprotective Therapy. Explor Neuroprot Ther. 2024; 4:442–58 | https://doi.org/10.37349/ent.
Goya RG, Gallardo MD, Girard M, Lehmann M, Hereñú CB. Hippocampal and reproductive aging in female rats- emerging rejuvenation strategies. J Clin Exp Reprod Med. 2024;1(1):8-11. Short Communication
Macarena Lorena Herrera, Leandro Gabriel Champarini, Osvaldo Martín Basmadjian, María José Bellini and Claudia Beatriz Hereñú. IGF-1 gene therapy prevents spatial memory deficits and modulates dopaminergic neurodegeneration and inflammation in a parkinsonism model. Brain Behav Immun. 2024 Jul;119:851-866. doi: 10.1016/j.bbi.2024.05.013. Epub 2024 May 16.PMID: 38750702
Priscila Chiavellini, Marianne Lehmann, Maria D. Gallardo, Martina Canatelli Mallat, Diana C. Pasquini, Joseph A. Zoller, Juozas Gordevicius, Mauricio Girard, Ezequiel Lacunza, Claudia B. Herenu, Steve Horvath, Rodolfo G. Goya. Young plasma rejuvenates blood DNA methylation profile, extends mean lifespan and improves physical appearance in old rats. Journal of Gerontology: Biological Sciences-JGBS J Gerontol A Biol Sci Med Sci. 2024 May 1;79(5): glae071. doi: 10.1093/gerona/glae071. PMID: 38430547.
Horvath S, Singh K, Raj K, Khairnar SI, Sanghavi A, Shrivastava A, Zoller JA, Li CZ, Herenu CB, Canatelli-Mallat M, Lehmann M, Habazin S, Novokmet M, Vučković F, Solberg Woods LC, Martinez AG, Wang T, Chiavellini P, Levine AJ, Chen H, Brooke RT, Gordevicius J, Lauc G, Goya RG, Katcher HL. Reversal of biological age in multiple rat organs by young porcine plasma fraction. Geroscience. 2024 Feb;46(1):367-394. doi: 10.1007/s11357-023-00980-6. PMID: 37875652
Claudia Hereñú and Rosana Crespo. Phytochemicals as estrogen receptor modulators?- a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in the treatment of non-small cell lung cancer. Transl Cancer Res. 2023 Dec 31;12(12):3249-3254. doi: 10.21037/tcr-23-1440. Epub 2023 Nov 27.PMID: 38197069
Horvath S, Singh K, Raj K, Khairnar S, Sanghavi A, Shrivastava A, Zoller JA, Li CZ, Herenu CB, Canatelli-Mallat M, Lehmann M, Habazin S, Novokmet M, Vučković F, Solberg Woods LC, Martinez AG, Wang T, Chiavellini P, Levine AJ, Chen H, Brooke RT, Gordevicius J, Lauc G, Goya RG, Katcher HL. Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction. bioRxiv. 2023 Aug 7:2023.08.06.552148. doi:10.1101/2023.08.06.552148. Preprint.PMID: 37609328 Free PMC article. Updated
Champarini L, Herrera ML, Comas Mutis RG, Espejo PJ, Molina VA, Calfa GD*, Hereñú CB*. *Equal contribution Effect of intra-BLA overexpression of IGF-1 on the expression of a contextual fear memory trace Hippocampus. 2022 Oct;32(10):765-775. doi: 10.1002/hipo.23465. Epub 2022 Aug 24.PMID: 36000813 Impact factor: 3,25
Chiavellini P, Lehmann M, Canatelli Mallat M, Zoller JA, Herenu CB, Morel GR, Horvath S, Goya RG . Hippocampal DNA Methylation, Epigenetic Age and Spatial Memory Performance in Young and Old Rats. J Gerontol A Biol Sci Med Sci. 2022 Dec 29;77(12):2387-2394. doi: 10.1093/gerona/glac153.PMID: 35917578
Eugenia Falomir-Lockhart, Franco Dolcetti, Macarena Herrera, Jerónimo Pennini, María Florencia Zappa Villar, Gabriela Salinas, Enrique Portiansky, Björn Spittau, Ezequiel Lacunza, Claudia B. Hereñú*, Maria Jose Bellini 1*. * Equally contribution to this work. IGF-1 gene transfer modifies microglia phenotype and gene expression in the Caudate-Putamen of female aged rat brain – Mol Neurobiol. 2022 Mar 19. doi: 10.1007/s12035-022-02791-w.
Chiavellini P, Canatelli-Mallat M, Lehmann M, Gallardo MD, Herenu CB, Cordeiro JL, Clement J, Goya RG. Aging and rejuvenation – a modular epigenome model. Aging (Albany NY). 2021 Feb 24;13(4):4734-4746. doi: 10.18632/aging.202712. Epub 2021 Feb 24.PMID: 33627519
Montivero AJ, Ghersi MS, Silvero C MJ, Artur de la Villarmois E, Catalan-Figueroa J, Herrera M, Becerra MC, Hereñú CB, Pérez MF. Early IGF-1 Gene Therapy Prevented Oxidative Stress and Cognitive Deficits Induced by Traumatic Brain Injury. Front Pharmacol. 2021 Jun 21;12:672392. doi: 10.3389/fphar.2021.672392. eCollection 2021.PMID: 34234671
Herrera M., Basmadjian OM., Falomir Lockhart E., Dolcetti FJC., Hereñú CB.*, Bellini MJ.*. Corresponding authors: Hereñú C. and Bellini MJ. Sex-frailty differences in aging mice: neuropathologies and therapeutic projections. Eur J Neurosci. 2020 Feb 12. doi: 10.1111/ejn.14703.- Bioxbio Journal . *These two authors contributed equally to this work.
Fabián Nishida, Carolina N. Zanuzzi , María S. Sisti , Eugenia Falomir Lockhart , Agustina E. Camiña, Claudia B. Hereñú, María J. Bellini, Enrique L. Portiansky . Intracisternal IGF-1 gene therapy abrogates kainic acid-induced excitotoxic damage of the rat spinal cord. Eur J Neurosci. 2020 Sep;52(5):3339-3352. doi: 10.1111/ejn.14876.
Herrera M.L.a, Ghersi M.S.a, Artur de la Villarmois E.a, Deza-Ponzio R.a, Virgolini M a, Pérez MF.a, Molina VA.a, Bellini MJ.b* and Hereñú CB.a*. * These two authors contributed equally to this work a(IFEC-CONICET-UNC) b(INIBIOLP-CONICET-UNLP). Corresponding authors: Hereñú C. and Bellini MJ. Early cognitive impairment behind nigro-striatal circuit neurotoxicity: are astrocytes involved? ASN Neuro mayo 2020. Doi: 10.1177/1759091420925977
Herrera M., Basmadjian OM., Falomir Lockhart E., Dolcetti FJC., Hereñú CB.*, Bellini MJ.*. * These two authors contributed equally to this work. Novel adenoviral IGF-I administration modulates the association between depressive symptoms and aging: Does gender matter?”. Corresponding authors: Hereñú C. and Bellini MJ. Behavioural Brain Research . 2019 Jun 20;372:112050. doi: 10.1016/j.bbr.2019.112050.
Falomir-Lockhart E, Dolcetti FJC, García-Segura LM, Hereñú CB*, Bellini MJ*. *These two authors contributed equally to this work. IGF1 Gene Therapy Modifies Microglia in the Striatum of Senile Rats.Corresponding authors: Hereñú C. and Bellini MJ. Front Aging Neurosci. 2019 Mar 5; 11:48. doi: 10.3389/fnagi.2019.00048. eCollection 2019
Lehmann M, Canatelli-Mallat M, Chiavellini P, Morel GR, Reggiani PC, Hereñú CB, Goya RG. Regulatable adenovector harboring the GFP and Yamanaka genes for implementing regenerative medicine in the brain.Gene Ther. 2019 Feb 15. doi: 10.1038/s41434-019-0063-x
Herrera Macarena Lorena, Champarini Leandro Gabriel, Otamendi Andrea, Hereñú Claudia Beatriz. Fearing Parkinson’s disease: relationships between cognition and emotion. (Book Chapter) Psychiatry and Neuroscience Update. 4th Edition © Springer International Publishing Switzerland – ISBN 978-3-319-17102-9 (eBook) 2018- Editores: Gargiulo, Pascual Angel, Mesones Arroyo, Humberto Luis (Eds.) (2018). 4th Edition. ISBN 978-3-319-95360-1 (Book Chapter)
Romina Deza-Ponzioa*, Macarena L. Herreraa,b*, María J.Bellinib, Miriam B. Virgolinia and Claudia B. Hereñúa. Corresponding author: Hereñú C. Aldehyde Dehydrogenase 2 in the spotlight: the link between mitochondria and neurodegeneration. Neurotoxicology. 2018 Jun 21; 68:19-24.