Maria Florencia Constantin, Emilce Artur de la Villarmois, José Leonardo Bravo, Aida Marcotti, Marisa Ghersi, Facundo Castro, Gastón Diego Calfa, María Dolores Rubianes & Mariela Fernanda Pérez
PMID: 40383851 – DOI: 10.1007/s00213-025-06806-x
Abstract
Rationale
Sildenafil, a phosphodiesterase-5 inhibitor, crosses the blood–brain barrier, enhancing cGMP signaling, dopamine neurotransmission, and hippocampal plasticity—key mechanisms for learning and memory.