Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson’s disease

Aracely Janneth Naranjo-Viteri, Matías Jávega Cometto, Matías Caverzan, Leandro Gabriel Champarini, María Paula Zunino, Rogelio E. Abburra, Claudia B. Hereñú, Rosana Crespo.

https://doi.org/10.1016/j.prmcm.2025.100584

Abstract

Essential oil (EO) of eucalyptus has been commonly used as a traditional Chinese medicine to treat illnesses such as influenza, dysentery and eczema, and it is widely used in the pharmaceutical industry. However, its neuroprotective effects have not been fully demonstrated. Given the rising prevalence of the neurodegenerative disorder, Parkinson’s disease, in aging populations, this study aims to investigate the effect of Eucalyptus globulus EO (EuEO) in a rat Parkinson model induced by bilateral lesion with the neurotoxin, 6-hydroxydopamine (6-OHDA).

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